DR. GEORGE SCHEELE

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  1. Morris, R.E., Robinson, P.R., and Scheele, G.A. (1964) The relationship of angiotensin to renal hypertension. Canad. Med. Assn. J. 90: 272-279.
  2. Scheele, G.A. and Kitzes, G. (1969) Analysis of academic training programs in Gastroenterology for the 10 year period 1957-1967, Gastroenterology, 57: 203-215.
  3. Scheele, G. and Palade, G. (1975) Studies on the pancreas of the guinea pig - parallel discharge of exocrine enzyme activities, J. Biol. Chem. 250: 2660-70.
  4. Tartakoff, A., Jamieson, J., Scheele, G., and Palade, G. (1975) Studies on the pancreas of the guinea pig - parallel processing and discharge of exocrine protein. J. Biol. Chem. 250: 2671-81.
  5. Scheele, G. (1975) Two dimensional gel analysis of soluble proteins - Characterization of guinea pig exocrine pancreatic proteins. J. Biol. Chem. 250: 5375-85.
  6. Devillers-Thiery, A., Kindt, T., Scheele, G., and Blobel, G. (1975) Homology in the amino-terminal sequence of precursors to pancreatic secretory proteins. Proc. Nat'l Acad. Sci. , USA , 72: 5016-20.
  7. Haymovits, A. and Scheele, G. (1976) Cellular cyclic nucleotides and enzyme secretion in the pancreatic acinar cell. Proc. Nat'l Acad. Sci. , USA , 73: 156-60.
  8. Scheele, G. (1976) Role of calcium in secretion, In Proceedings of the Cystic Fibrosis Foundation, pp 3-4.
  9. Scheele, G.A. (1976) Secretory proteins of the exocrine pancreas. In Cell Biology (PL Altman and DD Katz, eds., Federation of American Societies for Experimental Biology, Bethesda , MD , pp 334-6.
  10. Scheele, G., Dobberstein, B. and Blobel, G. (1978) Transfer of proteins across membranes. Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur. J. Biochem. 82: 593-9.
  11. Scheele, G and Haymovits, A (1978) Calcium dependent discharge of secretory proteins in guinea pig pancreatic lobules. In Calcium Transport and cell Function (eds. A Scarpa and E Carafoli), Annals of the NY Academy of Sciences , 307: pp 648-52.
  12. Scheele, G, Palade, G, and Tartakoff, A (1978) Cell fractionation studies on the guinea pig pancreas. Redistribution of exocrine proteins during tissue homogenization. J. Cell Biol. 78: 110-30.
  13. Scheele, G and Haymovits, A (1979) Cholinergic and peptide stimulated discharge of secretory proteins in guinea pig pancreatic lobules: Role of intracellular and extracellular calcium, J. Biol. Chem. 254: 10346-53.
  14. Scheele, G. and Blackburn , P. (1979) Role of the mammalian ribonuclease inhibitor in cell-free protein synthesis. Proc. Nat'l. Acad. Sci. , USA , 76: 4898-4902.
  15. Scheele, G. (1979) The secretory process in the pancreatic exocrine cell, Mayo Clinic Proceedings, 54: 420-7.
  16. Scheele, G. (1980) Biosynthesis, segregation, and secretion of exportable proteins in the exocrine pancreas. Am. J. Physiol. 1: G467-77.
  17. Bieger, W and Scheele, G (1980) A sensitive and specific assay for elastase activity using 3 H elastin as substrate. Anal. Biochem. 104: 239-46.
  18. Scheele, G and Haymovits, A (1980) Potassium and ionophore A23187 induced discharge of secretory protein in guinea pig pancreatic lobules: Role of extracellular calcium, J. Biol. Chem. 255: 4918-27.
  19. Iacino, D., Scheele, G., and Liebow, C. (1980) Secretory response of the rabbit pancreas to cholecystokinin-pancreozymin stimulation, Am. J. Physiol. 239: G247-54.
  20. Bieger, W. and Scheele, G. (1980) Two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis of protein mixtures containing active or potentially active proteases. Analysis of human exocrine pancreatic proteins, Anal. Biochem. 109: 222-230.
  21. Scheele, G. (1980) Human pancreatic cancer: Analysis of proteins contained in pancreatic juice by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Cancer, 47: 1513-15.
  22. Bartelt, D.C. and Scheele, G. (1980) Calmodulin and calmodulin-binding proteins in canine pancreas, Ann. NY Acad. Sci., 356: 356-357
  23. Scheele, G., Jacoby, R. and Carne, T. (1980) Mechanism of compartmentation of secretory proteins I. Transport of exocrine pancreatic proteins across the microsomal membrane. J. Cell Biol. 87: 611-28.
  24. Scheele, G., Pash, J. and Bieger, W. (1981) Identification of proteins according to biological activity following separation by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis - Analysis of human exocrine pancreatic proteins. Anal. Biochem. 112: 304-13.
  25. Scheele, G., Bartelt, D. and Bieger, W. (1981) Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology, 80: 461-73.
  26. Rohr, G., Kern, H. and Scheele, G. (1981) Enteropancreatic circulation of digestive enzymes does not exist in the rat. Nature, 292: 470-72.
  27. Scheele, G. (1981) Analysis of the secretory process in the exocrine pancreas by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. In Methods in Cell Biology (A. Hand and C. Oliver, eds.), 23: 345-58.
  28. Scheele, G. (1982) Pancreatic zymogen granules, In The Secretory Granule (A. Poisner and J. Trifaro, eds.) Elsevier Biomedical Press, pp 213-46.
  29. Carne, T. and Scheele, G. (1982) Amino acid sequences of transport peptides associated with canine pancreatic proteins. J. Biol. Chem. 257, 4133-40.
  30. Scheele, G. and Jacoby, R. (1982) Conformational changes associated with proteolytic processing of presecretory proteins allow glutathione-catalyzed formation of native disulfide bonds. J. Biol. Chem. 257, 12277-82.
  31. Scheele, G. and Jacoby, R. (1983) Proteolytic processing of presecretory proteins is required for development of biological activities in pancreatic exocrine proteins, J. Biol. Chem. 258: 2005-9.
  32. Carne, T. and Scheele, G. (1983) The role of presecretory proteins in the secretory process. In The Secretory Process (ed. Marc Cantin) Karger Press, Basel , Switzerland , pp 73-101.
  33. Scheele, G. (1983) Methods for the study of protein translocation across the RER membrane using the reticulocyte lysate translation system and canine pancreatic microsomal membranes. In Methods in Enzymology, Biomembranes (eds. S. Fleicher and B. Fleicher) 96: 94-110.
  34. Rohr, G. and Scheele, G. (1983) Transcellular transport of proteins studied in vivo, In Methods in Enzymology, Biomembranes (eds. S. Fleicher and B. Fleicher), 98: 17-27.
  35. Scheele, G. (1983) pancreatic Lobules in the in vitro study of pancreatic acinar cell function, In Methods in Enzymology, Biomembranes (eds. S. Fleicher and B. Fleicher), 98: 17-27.
  36. Scheele, G. (1982) Two dimensional electrophoresis in basic and clinical research as exemplified by studies on the exocrine pancreas, Clin. Chem., 28: 1056-61.
  37. Bartelt , D.C. , Carlin, R.C., Scheele, G.A. and Cohen, W.D. (1982) The cytoskeletal system of nucleated erythrocytes, II. Presence of a high molecular weight calmodulin binding protein, J. Cell Biol. 95: 278-84.
  38. Bartelt, D.D., Carlin, R.K., Scheele, G.A. and Cohen, W.D. (1984) Similarities between the Mr 245,000 calmodulin-binding protein of the dogfish erythrocyte cytoskeleton and alpha-fodrin, Arch. Biochem. Biophys. 230: 18-20.
  39. Rohr, G. and Scheele, G. (1983) Fate of radioactive exocrine pancreatic proteins injected into the blood circulation of the rat. Tissue uptake and transepithelial excretion, Gastroenterology, 85: 991-1002.
  40. Schick, J., Beil-Moeller, H., Kern, H.F. and Scheele, G.A. (1982) Differential rates of synthesis of individual pancreatic enzymes during prolonged in vivo stimulation, In Mechanisms of Intestinal adaptation (Robinson, JWL, Dowling, RH, Riecken, EO, eds.), MTP Press, pp 511-514.
  41. Schick, J., Kern, H. and Scheele, G. (1984) Hormonal stimulation in the exocrine pancreas results in coordinate and anticoordinate regulation of protein synthesis, J. Cell Biol. 99: 1559-64.
  42. Schick, J., Verspohl, R., Kern, H. and Scheele, G. (1984) Two distinct genetic patterns of response in the exocrine pancreas to inverse changes in protein and carbohydrate in the diet, Am. J. Physiol. 248: G611-616.
  43. Wicker, C., Puigserver, A. and Scheele, G. (1984) Dietary regulation of levels of active mRNA coding for amylase and serine protease zymogens in the rat pancreas, Eur. J. Biochem. 139: 381-387.
  44. Wicker, C., Scheele, G. and Puigserver, A. (1983) Adaptation au regime alimentaire du niveau des ARNm codant pour l'amylase et les proteases a serine pancreatiques chez le rat, C. R. Acad. Sc. Paris, 297: 281-284.
  45. Kern, H., Adler, G. and Scheele, G. (1984) Concept of flow and compartmentation in understanding the pathobiology of pancreatitis. In Pancreatitis, Concepts and Classification (eds. Gyr, K., Singer, M. and Sarles, H.) Elsevier Biomedical Press, pp 3-9.
  46. Scheele, G., Adler, G. and Kern, H. (1984) The role of lysosomes in the development of acute pancreatitis, In Pancreatitis, Concepts and Classification (eds. K. Gyr, M. Singer and H. Sarles) Elsevier Biomedical Press, pp 17-23.
  47. Kern, H., Warshaw, A. and Scheele, G. (1984) Fine structure of protein precipitations in acinar luminae in the normal human pancreas and in pancreatitis, In Pancreatitis, Concepts and Classification (eds. K. Gyr, M. Singer, and H. sarles) Elsevier Biomedical Press, pp 101-105.
  48. Scheele, G. (1984) Analysis of human exocrine proteins in health and disease by use of two dimensional isoelectric focusing/SDS gel electrophoresis. In Pancreatitis, Concepts, and Classification (eds. K. Gyr, M. Singer, and H. Sarles) Elsevier Biomedical Press, pp 89-94
  49. Scheele, G. (1984) Biochemical concepts and markers in pancreatitis, In Pancreatitis, Concepts and Classification (eds. K. Gyr, M. Singer and H. Sarles) Elsevier Biomedical Press, pp119-125.
  50. Kern, H., Adler, G. and Scheele, G. (1985) Structural and biochemical characterization of maximal and supramaximal hormonal stimulation in the rat exocrine pancreas, Scand. J. Gastroenterology [Suppl.] 112: 20-29.
  51. Scheele, G. (1986) Early biochemical events in the biogenesis and topogenesis of secretory and membrane proteins, In Molecular and Cellular Biology of Digestion (P. Desnuelle, H. Sjostrom, and O. Noren, eds.) Elsevier Biomedical Press, pp 43-59.
  52. Scheele, G. and Kern, H. (1986) The exocrine pancreas, In Molecular Cellular Biology of Digestion (P. Desnuelle, H. Sjostrom, and O. Noren, eds.) Elsevier Biomedical Press, pp 173-194.
  53. Adler, G., Kern, H. and Scheele, G. (1986) Experimental models and concepts in acute pancreatitis, In The Exocrine Pancreas: Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardner, F.P. Brooks, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press. New York , NY , pp 407-421.
  54. Scheele, G. (1986) Two dimensional electrophoresis in the analysis of exocrine pancreatic proteins, In The Exocrine Pancreas: Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardner, F.P. Brooks, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press. New York , NY , pp 185-192.
  55. Scheele, G. (1986) Cellular processing of proteins in the exocrine pancreas, In The Exocrine Pancreas: Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardner, F.P. Brooks, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press. New York , NY , pp 69-85.
  56. Scheele, G. (1986) Regulation of gene expression in the exocrine pancreas, In The Exocrine Pancreas: Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardner, F.P. Brooks, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press. New York , NY , pp 55-67.
  57. Ptichumoni, C.S., Scheele, G.A., Lee, P.C., Lebenthal, E. (1986) Effects of nutrition on the exocrine pancreas, In The Exocrine Pancreas: Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardner, F.P. Brooks, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press. New York , NY , pp 387-406.
  58. Scheele, G. and Tartakoff, A. (1985) Exit of nonglycosylated secretory proteins from the RER is asynchronous in the exocrine pancreas, J. Biol. Chem. 260: 926-931.
  59. Pinsky, S., LaForge, S., Luc, V. and Scheele, G. (1983) Identification of cDNA clones encoding specific secretory isoenzyme forms; Determination of the primary structure of dog pancreatic prechymotrypsinogen 2 mRNA, Proc. Nat'l. Acad. Sci. , USA , 80: 7486-7490.
  60. Wicker, C., Puigserver, A., Rausch, U., Scheele, G. and Kern, H. (1985) Multiple level caerulein control of the gene expression of secretory proteins in the rat pancreas. Eur. J. Biochem. 151: 461-466.
  61. Pinsky, S.,LaForge, K. S., and Scheele, G. (1985) Differential regulation of trypsinogen mRNA translation: Full-length mRNA sequences encoding two oppositely charged trypsinogen isoenzymes in the dog pancreas. Mol. and Cell. Biol. 5: 2669-2676.
  62. Kerfelec, B., LaForge, K.L., Puigserver, A. and Scheele, G. (1986) Primary structures of canine pancreatic lipase and phospholipase A 2 messenger RNAs, Pancreas, 1: 430-437.
  63. Bartelt, D., Wolff, D. and Scheele, G. (1986) Calmodulin-binding proteins and calmodulin-regulated enzymes in dog pancreas. Biochem. J. 240: 753-763.
  64. Kern, H., Rausch, U. and Scheele, G. (1986) Pancreatic adaptation to nutritional substrates in the diet is regulated by specific hormones, In Adaptation in the Small Instestine and Pancreas (H. Dowling, U. Folsch and E.O. Riecken, eds.) Gut, 28: 89-94.
  65. Rausch, U., Vasiloudes, P., Rudiger, K., Kern, H. and Scheele, G. (1986) Lipase synthesis in the rat pancreas is regulated by secretin, Pancreas, 1: 522-528.
  66. Lutcke, H., Scheele, G. and Kern, H. (1987) Time course and cellular site of mitotic activity in the rat exocrine pancreas during sustained hormone stimulation, Cell Tiss. Res., 247: 364-370.
  67. Scheele, G., Adler, G. and Kern, H. (1987) Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation, Gastroenterology, 92: 345-353.
  68. Lutcke, H., Chow, K-C., Mickel, S., Moss, K., Kern, H. and Scheele, G. (1987) Selection of AUG initiation codons differs in plants and animals. EMBO J. 6: 43-48.
  69. Steinhilber, W., Poensgen, J., Rausch, U., Kern, H. and Scheele, G. (1988) Translational control of anionic trypsinogen and amylase synthesis in rat pancreas in response to caerulein stimulation. Proc. Nat'l Acad. Sci. , USA , 85: 6597-6601.
  70. Wicker, C., Scheele, G.A. and Puigserver, A. (1988) pancreatic adaptation to dietary lipids is mediated by changes in lipase mRNA. Biochimie, 70: 1277-1283.
  71. Scheele, G.A. (1988) Molecular sorting of proteins into the cisternal secretory pathway, Biochimie, 70: 1269-1276.
  72. Swarovsky, B., Steinhilber, W., Scheele, G.A. and Kern, H.F. (1988) Coupled induction of exocrine proteins and intracellular compartments involved in the secretory pathway in AR4-2J cells by glucocorticoids, Eur. J. Cell Biol. 47: 101-111.
  73. Mickel, F.S., Weidenbach, F., Swarovsky, B., LaForge, K.S., Scheele, G.A. (1989) Structure of the canine pancreatic lipase gene. J. Biol. Chem. 264: 12895-12901.
  74. Scheele, G. and Kern, H.F. (1989) Cellular compartmentation and protein processing in the exocrine pancreas. Handbook Physiol., Section 6, The Gastrointestinal System, Vol. III, salivary, gastric, pancreatic and hepatobiliary secretion (J. Forte, ed.) Oxford University Press, NY, pp 477-498.
  75. Scheele, G. and Kern H.F. (1989) Selective regulation of gene expression in the exocrine pancreas. Handbook Physiol., Section 6, The Gastrointestinal System, Vol. III, salivary, gastric, pancreatic and hepatobiliary secretion (J. Forte, ed.) Oxford University Press, NY, pp 499-513.
  76. Lutcke, H., Rausch, U., Vasiloudes, P., Scheele, G.A. and Kern, H.F. (1989) A fourth trypsinogen (P23) in the rat pancreas induced by CCK, Nuc. Acids Res., 17: 6736.
  77. Fukuoka , S.-I. And Scheele, G.A. (1989) Complementary nucleotide sequence for monitor peptide, a novel cholecystokinin-releasing peptide in the rat, Nuc. Acids Res. 17: 10111.
  78. Fukuoka , S.-I. And Scheele, G.A. (1990) Rapid and selective cloning of monitor peptide, a novel CCK-releasing peptide, using minimal amino acid sequence and the polymerase chain reaction. Pancreas, 5: 1-7.
  79. Kerfelec, B., LaForge, K.S., Vasiloudes, P., Puigserver, A. and Scheele, G. (1990) Isolation and sequence of the canine pancreatic phospholipase A 2 gene, Eur. J. Biochem., 190: 299-304.
  80. Fukuoka , S.-I., Taniguchi, Y., Kitigawa, Y. and Scheele, G.A. (1990) Full-length cDNA sequence encoding canine pancreatic colipase, Nuc. Acids Res., 18: 5549.
  81. Fukuoka , S.-I. And Scheele, G.S. (1990) Nucleotide sequence encoding the major glycoprotein (GP2) of rat pancreatic secretory (zymogen) granule membranes. Nuc. Acids Res. 18: 5900.
  82. Fukuoka, S.-I., Freedman, S.D. and Scheele, G.A. (1991) A single gene encodes membrane bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. Proc. Nat. Acad. Sci., USA , 88: 2898-2902.
  83. Leach, S.D., Modlin, I.M., Scheele, G.A. and Gorelick, F.S. (1991) Intracellular activation of digestive zymogens in rat pancreatic acini, Stimulation by high doses of cholecystokinin, J. Clin. Invest. 87: 362-366.
  84. Fukuoka , S.-I. And Scheele, G.A. (1991) Novel strategy for synthesis of full-length double-stranded cDNA transcripts without dC-dG tails. Nuc. Acids Res. 19: 6961-6962.
  85. Fukuoka , S.-I., Freedman, S.D., Yu, H., Sukhatme, V. and Scheele, G.A. (1992) GP2/THP gene family encodes self-binding GPI-linked proteins in apical vesicular membranes of pancreas and kidney, Proc. Nat'l. Acad. Sci. , USA , 89: 1189-1193.
  86. Freedman, S.D., and Scheele, G.A. (1993) Regulated secretory proteins in the exocrine pancreas aggregate under conditions that mimic the trans-Golgi network, Biochem. Biophys. Res. Comm. 2: 992-999.
  87. Padfield, P.J. and Scheele, G.A. (1993) The use of two-dimensional gel electrophoresis and high performance liquid chromatography for the analysis of pancreatic juice, In The Pancreas, Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardiner, H.A. Reber, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press, New York , NY pp 265-273.
  88. Ptichumoni, C.S. and Scheele, G.A. (1993) Interdependence of nutrition and exocrine pancreatic function, In The Pancreas, Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardiner, H.A. Reber, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press, New York , NY pp 449-473.
  89. Scheele, G. (1993) Regulation of pancreatic gene expression in response to hormones and nutritional substrates, In The Pancreas, Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardiner, H.A. Reber, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press, New York , NY pp 103-120.
  90. Scheele, G.A. and Kern, H.F. (1993) Cellular compartmentation, protein processing and secretion in the exocrine pancreas, In The Pancreas, Biology, Pathobiology and Diseases (V.L. Go, J.D. Gardiner, H.A. Reber, E. Lebenthal, E.P. DiMagno, G.A. Scheele, eds.) Raven Press, New York , NY pp 121-150.
  91. Fukuoka , S.I., Zhang, D.-E., Taniguchi, Y. and Scheele, G.A. (1993) Structure of the pancreatic colipase gene includes two protein binding sites in the promoter region, J. Biol. Chem. 11312-11320.
  92. Freedman, S.D. and Scheele, G.A. (1993) Reversible pH-induced homophilic binding of GP2, a glycosyl-phosphatidylinositol-anchored protein in pancreatic zymogen granule membranes. Eur. J. Cell Biol. 61: 229-238.
  93. Scheele, G.A. (1993) Extracellular and intracellular messengers in diet-induced regulation of pancreatic gene expression, In Physiology of the Gastrointestinal Tract (L.R. Johnson, ed.) Raven Press, New York , NY ,
  94. Freedman, S.D. Sakamoto, K. and Scheele, G.A. (1993) Nonparallel secretion of GP2, a GPI-linked protein in exocrine pancreas, implies luminal coupling reactions between acinar and duct cells, Am. J. Physiol., 267: G40-G51.
  95. Wada, I., Ou, W.-J., Lew, M.C., Scheele, G.A. (1994) Chaperone function of calnexin for the folding intermediate of gp80, the major secretory protein in MDCK cells, J. Biol. Chem. 269: 7464-7472.
  96. Freedman, S.D. and Scheele, G.A. (1994) Acid-Base interactions during exocrine pancreatic secretion. Primary role for ductal bicarbonate in acinar lumen function. Annals NY Acad. Sci. 713: 199-206.
  97. Scheele, G.A., Fukuoka , S.-I., Freedman, S.D. (1994) Role of the GP2/THP family of GPI-anchored proteins in membrane trafficking during regulated exocrine secretion. Pancreas, 9: 139-149.
  98. Freedman, S.D., Kern, H.F. and Scheele, G.A. (1994) Apical membrane trafficking during regulated pancreatic exocrine secretion - Role of alkaline pH in the acinar lumen and enzymatic cleavage of GP2, a GPI-linked protein, Eur. J. Cell Biol. 65: 354-365.
  99. Bimmler, D., Frick, T.W. and Scheele, G.A. (1995) High level secretion of native rat pancreatic lithostatine in a baculovirus expression system, Pancreas, 11: 63-76.
  100. Scheele, G.A., Fukuoka, S.-I., Kern, H.F. and Freedman, S.D. (1996) Pancreatic dysfunction in cystic fibrosis occurs as a result of impairment in luminal pH, apical trafficking of zymogen granule membranes, and solubilization of secretory enzymes. Pancreas, 1: 1-9.
  101. Bimmler, D., Graf, R., Scheele, G.A. and Frick, T.W. (1997) Pancreatic stone protein (lithostathine), a physiologically relevant pancreatic calcium crystal inhibitor? J. Biol. Chem. 272: 3073-82.
  102. Freedman, S.D., Scheele, G.A. and Kern, H.F. (1997) Coupling of ductal and acinar cell function in the exocrine pancreas: novel insights into CF. Pediatric Pulmonology, [Suppl. 14] 24: 114-115.
  103. Gorelick, F.S., Schmid, S.W., Tang, L.H., Rhee, S., Nathanson, M., Scheele, G.A., Modlin, I.M. (1998) Telenzepine-sensitive muscarinic receptors on the pancreatic acinar cell, Am. J. Physiol. 274: G734-41.
  104. Freedman, S.D., Kern, H.F. and Scheele, G.A. (1998) Acinar lumen pH regulates endocytosis, but not exocytosis, at the apical plasma membrane of pancreatic acinar cells, Eur. J. Cell Biol., 75: 153-162.
  105. Freedman, S.D., Kern, H.F. and Scheele, G.A. (1998) Cleavage of GPI-anchored proteins from the plasma membrane activates apical endocytosis in pancreatic acinar cells, Eur. J. Cell Biol., 75: 163-173.
  106. Bimmler, D., Angst, E., Valeri, F., Bain, M., Scheele, G.A., Frick, T.W. and Graf, R. (1999) Regulation of PSP/ reg in Rat Pancreas: Immediate and Steady State Adaptation to Different Diets, Pancreas, 19: 255-267.
  107. Graf, R., Schiesser, M., Scheele, G.A., Marquardt, K., Frick, T.W., Ammann, R. and Bimmler, D. (2001) A Family of 16-kDa Pancreatic Secretory Stress Proteins Form Highly Organized Fibrillar Structures upon Tryptic Activation. J. Biol. Chem., 276: 21028-21038.
  108. Freedman, S.D., Kern, H.F. and Scheele, G.A. (2001) Pancreatic Acinar Cell Dysfunction in CFTR-/- Mice is Associated with Impairments in Luminal pH and Endocytosis at the apical Plasma Membrane. Gastroenterology, 121: 950-957.
  109. Graf, R., Schiesser, M., Lussi, A., Went, P., Scheele, G.A. Bimmler, D. (2002) Coordinate regulation of Secretory stress proteins (PSP/reg and PAPI, II & III during experimental acute pancreatitis. Journal of Surgical Research. 15;105(2):136-44.
  110. Bimmler, D., Schiesser, M., Perren, A., Scheele, G., Angst, E., Meili, S., Ammann R. and Graf R. (2003) Coordinate Regulation of PSP/reg and PAP Isoforms as a Family of secretory Stress Proteins in an Animal Model of Chronic. Accepted for publication in the Journal of Surgical Research

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