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Kinetics of movement of the
entire cadre of secretory enzymes through
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sequential intracellular compartments
during the biogenesis and secretion of
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pancreatic enzymes.
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Kinetic of release of all secretory
enzymes from the acinar cell during
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conditions of rest and secretagogue
stimulation.
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Folding of nascent pancreatic
enzymes following their sequestration into the
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RER lumen.
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Kinetics of activation of
pancreatic proteases leading to the autoactivation
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of pancreatic juice, a pathological
process believed to play a role in the
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pathogenesis of acute and chronic
pancreatitis in humans.
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Gene and protein expression studies
of families of pancreatic enzymes as a
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function of changes in ratios of
nutritional substrates in the diet and as a
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function of secretagogue stimulation.
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